A single injection of crystallizable fragment domain–modified antibodies elicits durable protection from SHIV infection

In the absence of an effective and safe vaccine against HIV-1, the administration of broadly neutralizing antibodies (bNAbs) represents a logical alternative approach to prevent virus transmission. Here, we introduced two mutations encoding amino acid substitutions (M428L and N434S, collectively ref...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Med
Prif Awduron: Gautam, Rajeev, Nishimura, Yoshiaki, Gaughan, Natalie, Gazumyan, Anna, Schoofs, Till, Buckler-White, Alicia, Seaman, Michael S., Swihart, Bruce J., Follmann, Dean A., Nussenzweig, Michel C., Martin, Malcolm A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group US 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989326/
https://ncbi.nlm.nih.gov/pubmed/29662199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0001-2
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