A single injection of crystallizable fragment domain–modified antibodies elicits durable protection from SHIV infection

In the absence of an effective and safe vaccine against HIV-1, the administration of broadly neutralizing antibodies (bNAbs) represents a logical alternative approach to prevent virus transmission. Here, we introduced two mutations encoding amino acid substitutions (M428L and N434S, collectively ref...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nat Med
Autori principali: Gautam, Rajeev, Nishimura, Yoshiaki, Gaughan, Natalie, Gazumyan, Anna, Schoofs, Till, Buckler-White, Alicia, Seaman, Michael S., Swihart, Bruce J., Follmann, Dean A., Nussenzweig, Michel C., Martin, Malcolm A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group US 2018
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989326/
https://ncbi.nlm.nih.gov/pubmed/29662199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0001-2
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi