Glucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance

Insulin resistance (IR) predisposes to type 2 diabetes and cardiovascular disease but its causes are incompletely understood. Metabolic challenges like the oral glucose tolerance test (OGTT) can reveal pathogenic mechanisms. We aimed to discover associations of IR with metabolite trajectories during...

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Vydáno v:Sci Rep
Hlavní autoři: Nowak, Christoph, Hetty, Susanne, Salihovic, Samira, Castillejo-Lopez, Casimiro, Ganna, Andrea, Cook, Naomi L., Broeckling, Corey D., Prenni, Jessica E., Shen, Xia, Giedraitis, Vilmantas, Ärnlöv, Johan, Lind, Lars, Berne, Christian, Sundström, Johan, Fall, Tove, Ingelsson, Erik
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989236/
https://ncbi.nlm.nih.gov/pubmed/29875472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26701-0
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