Exit from Naive Pluripotency Induces a Transient X Chromosome Inactivation-like State in Males

A hallmark of naive pluripotency is the presence of two active X chromosomes in females. It is not clear whether prevention of X chromosome inactivation (XCI) is mediated by gene networks that preserve the naive state. Here, we show that robust naive pluripotent stem cell (nPSC) self-renewal repress...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Sousa, Elsa J., Stuart, Hannah T., Bates, Lawrence E., Ghorbani, Mohammadmersad, Nichols, Jennifer, Dietmann, Sabine, Silva, José C.R.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989057/
https://ncbi.nlm.nih.gov/pubmed/29804891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.05.001
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