Anti-myeloma Effects of Icariin Are Mediated Through the Attenuation of JAK/STAT3-Dependent Signaling Cascade

Because of the essential role of signal transducer and activator of transcription 3 (STAT3) in proliferation, anti-apoptosis, and chemoresistance of multiple myeloma (MM), we investigated whether icariin, a prenylated flavonol glycoside, inhibits both constitutive and inducible STAT3 activation in h...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Jung, Young Yun, Lee, Jong Hyun, Nam, Dongwoo, Narula, Acharan S., Namjoshi, Ojas A., Blough, Bruce E., Um, Jae-Young, Sethi, Gautam, Ahn, Kwang Seok
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989039/
https://ncbi.nlm.nih.gov/pubmed/29899697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00531
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