GMP-Grade Manufacturing of T Cells Engineered to Express a Defined γδTCR

γ9δ2T cells play a critical role in daily cancer immune surveillance by sensing cancer-mediated metabolic changes. However, a major limitation of the therapeutic application of γ9δ2T cells is their diversity and regulation through innate co-receptors. In order to overcome natural obstacles of γ9δ2T...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Straetemans, Trudy, Kierkels, Guido J. J., Doorn, Ruud, Jansen, Koen, Heijhuurs, Sabine, dos Santos, Joao M., van Muyden, Anna D. D., Vie, Henri, Clemenceau, Béatrice, Raymakers, Reinier, de Witte, Moniek, Sebestyén, Zsolt, Kuball, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988845/
https://ncbi.nlm.nih.gov/pubmed/29899740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01062
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