Oncogene-induced senescence mediated by c-Myc requires USP10 dependent deubiquitination and stabilization of p14ARF

Oncogene-induced senescence (OIS) is a critical tumor-suppressor mechanism, which prevents hyper-proliferation and transformation of cells. c-Myc promotes OIS through the transcriptional activation of p14ARF followed by p53 activation. Although the oncogene-mediated transcriptional regulation of p14...

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Publicat a:Cell Death Differ
Autors principals: Ko, Aram, Han, Su Yeon, Choi, Chel Hun, Cho, Hanbyoul, Lee, Min-Sik, Kim, Soo-Youl, Song, Joon Seon, Hong, Kyeong-Man, Lee, Han-Woong, Hewitt, Stephen M., Chung, Joon-Yong, Song, Jaewhan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988833/
https://ncbi.nlm.nih.gov/pubmed/29472714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0072-0
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