Use of a charge reducing agent to enable intact mass analysis of cysteine-linked antibody-drug-conjugates by native mass spectrometry

Antibody-drug-conjugates (ADC) are a growing class of anticancer biopharmaceuticals. Conjugation of cysteine linked ADCs, requires initial reduction of mAb inter-chain disulfide bonds, as the drugs are attached via thiol chemistry. This results in the active mAb moiety being transformed from a coval...

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Detalhes bibliográficos
Publicado no:EuPA Open Proteom
Main Authors: Pacholarz, Kamila J., Barran, Perdita E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Special Section: Proceedings of the 9th Annual EuPA Congress “Proteomics - Back to the Future” (June 23 - 28, 2015, Milano, Italy)
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988552/
https://ncbi.nlm.nih.gov/pubmed/29900109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.euprot.2016.02.004
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