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Cryo-EM shows how dynactin recruits two dyneins for faster movement
Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence of an activating adaptor, such as BICD2. Different adaptors link dynein/dynactin to distinct cargos. Here we use electron microscopy (EM) and single molecule studies to show that adaptors can recruit a second...
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| Published in: | Nature |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5988349/ https://ncbi.nlm.nih.gov/pubmed/29420470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature25462 |
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