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Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses

In human patients, loss-of-function mutations of the postsynaptic cell-adhesion molecule neuroligin-4 were repeatedly identified as monogenetic causes of autism. In mice, neuroligin-4 deletions caused autism-related behavioral impairments and subtle changes in synaptic transmission, and neuroligin-4...

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Dades bibliogràfiques
Publicat a:J Exp Med
Autors principals: Zhang, Bo, Gokce, Ozgun, Hale, W. Dylan, Brose, Nils, Südhof, Thomas C.
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987923/
https://ncbi.nlm.nih.gov/pubmed/29724786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20172162
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