An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus

Neuroligins are evolutionarily conserved postsynaptic cell-adhesion molecules that function, at least in part, by forming trans-synaptic complexes with presynaptic neurexins. Different neuroligin isoforms perform diverse functions and exhibit distinct intracellular localizations, but contain similar...

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Main Authors: Etherton, Mark R, Tabuchi, Katsuhiko, Sharma, Manu, Ko, Jaewon, Südhof, Thomas C
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160244/
https://ncbi.nlm.nih.gov/pubmed/21642956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.182
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