Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes

β-amyloid protein (Aβ) plays a central role in the pathogenesis of Alzheimer disease (AD). Aβ is generated from sequential cleavage of amyloid precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) and the γ-secretase complex. Although activation of some protein kinase C (PKC) isoforms such...

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Bibliografiske detaljer
Udgivet i:J Exp Med
Main Authors: Du, Ying, Zhao, Yingjun, Li, Chuan, Zheng, Qiuyang, Tian, Jing, Li, Zhuyi, Huang, Timothy Y., Zhang, Wei, Xu, Huaxi
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2018
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987914/
https://ncbi.nlm.nih.gov/pubmed/29739836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171193
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