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Mdm2 selectively suppresses DNA damage arising from inhibition of topoisomerase II independent of p53
Mdm2 is often overexpressed in tumors that retain wild-type TP53 but may affect therapeutic response independently of p53. Herein is shown that tumor cells with MDM2 amplification are selectively resistant to treatment with topoisomerase II poisons but not other DNA damaging agents. Tumor cells that...
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| Yayımlandı: | Oncogene |
|---|---|
| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5987529/ https://ncbi.nlm.nih.gov/pubmed/28692049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.229 |
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