Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis

We tested whether inhibiting mechanically-responsive articular chondrocyte mitochondria after severe traumatic injury and preventing oxidative damage represent a viable paradigm for posttraumatic osteoarthritis (PTOA) prevention. We used a porcine hock intra-articular fracture (IAF) model well suite...

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Udgivet i:Sci Transl Med
Main Authors: Coleman, Mitchell C., Goetz, Jessica E., Brouillette, Marc J., Seol, Dongrim, Willey, Michael C., Petersen, Emily B., Anderson, Hope D., Hendrickson, Nathan R., Compton, Jocelyn T., Khorsand, Behnoush, Morris, Angie S., Salem, Aliasger K., Fredericks, Douglas C., McKinley, Todd O., Martin, James A.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987523/
https://ncbi.nlm.nih.gov/pubmed/29437147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan5372
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