Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis

We tested whether inhibiting mechanically-responsive articular chondrocyte mitochondria after severe traumatic injury and preventing oxidative damage represent a viable paradigm for posttraumatic osteoarthritis (PTOA) prevention. We used a porcine hock intra-articular fracture (IAF) model well suite...

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Detaylı Bibliyografya
Yayımlandı:Sci Transl Med
Asıl Yazarlar: Coleman, Mitchell C., Goetz, Jessica E., Brouillette, Marc J., Seol, Dongrim, Willey, Michael C., Petersen, Emily B., Anderson, Hope D., Hendrickson, Nathan R., Compton, Jocelyn T., Khorsand, Behnoush, Morris, Angie S., Salem, Aliasger K., Fredericks, Douglas C., McKinley, Todd O., Martin, James A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987523/
https://ncbi.nlm.nih.gov/pubmed/29437147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aan5372
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