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Complement-Mediated Activation of the NLRP3 Inflammasome and Its Inhibition by AAV-Mediated Delivery of CD59 in a Model of Uveitis
Uveitis is an inflammatory disorder of the eye responsible for approximately 10%–15% of blindness in the US. In this study, we examined the role of the complement membrane attack complex (MAC) and the NLRP3 inflammasome in the pathogenesis of experimental autoimmune uveitis (EAU) in normal and C9(−/...
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| Veröffentlicht in: | Mol Ther |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Gene & Cell Therapy
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5986727/ https://ncbi.nlm.nih.gov/pubmed/29678656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.03.012 |
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