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Strikingly different effects of cholesterol and 7-ketocholesterol on lipid bilayer-mediated aggregation of amyloid beta (1-42)

Oxidized cholesterol has been widely reported to contribute to the pathogenesis of Alzheimer's disease (AD). However, the mechanism by which they affect the disease is not fully understood. Herein, we aimed to investigate the effect of 7-ketocholesterol (7keto) on membrane-mediated aggregation...

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Veröffentlicht in:Biochem Biophys Rep
Hauptverfasser: Phan, Huong T.T., Shimokawa, Naofumi, Sharma, Neha, Takagi, Masahiro, Vestergaard, Mun'delanji C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986554/
https://ncbi.nlm.nih.gov/pubmed/29872741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2018.04.007
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