Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF CalDAG-GEFI

Platelets are recruited to sites of vascular injury, where they are activated and aggregate to form a hemostatic plug. This process requires the activation of the small GTPase Rap1B by its cognate guanine nucleotide exchange factor CalDAG-GEFI. Studies on platelet function suggest that CalDAG-GEFI a...

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Udgivet i:J Biol Chem
Main Authors: Cook, Aaron A., Deng, Wei, Ren, Jinqi, Li, Renhao, Sondek, John, Bergmeier, Wolfgang
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986229/
https://ncbi.nlm.nih.gov/pubmed/29622678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002712
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