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Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF CalDAG-GEFI
Platelets are recruited to sites of vascular injury, where they are activated and aggregate to form a hemostatic plug. This process requires the activation of the small GTPase Rap1B by its cognate guanine nucleotide exchange factor CalDAG-GEFI. Studies on platelet function suggest that CalDAG-GEFI a...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5986229/ https://ncbi.nlm.nih.gov/pubmed/29622678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002712 |
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