Structure-based energetics of protein interfaces guide Foot-and-Mouth Disease virus vaccine design

Virus capsids are primed for disassembly yet capsid integrity is key to generating a protective immune response. Here we devise a computational method to assess relative stability of protein-protein interfaces and use it to design improved candidate vaccines for two of the least stable, but globally...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Struct Mol Biol
Prif Awduron: Kotecha, Abhay, Seago, Julian, Scott, Katherine, Burman, Alison, Loureiro, Silvia, Ren, Jingshan, Porta, Claudine, Ginn, Helen M., Jackson, Terry, Perez-Martin, Eva, Siebert, C. Alistair, Paul, Guntram, Huiskonen, Juha T., Jones, Ian M., Esnouf, Robert M., Fry, Elizabeth E., Maree, Francois F., Charleston, Bryan, Stuart, David I.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985953/
https://ncbi.nlm.nih.gov/pubmed/26389739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3096
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