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Improved method for synthesis of low molecular weight protamine–siRNA conjugate

RNAi technology has aroused wide public interest due to its high efficiency and specificity to treat multiple types of diseases. However, the effective delivery of siRNA remains a challenge due to its large molecular weight and strong anionic charge. Considering their remarkable functions in vivo an...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Acta Pharm Sin B
Prif Awduron: Yu, Zhili, Ye, Junxiao, Pei, Xing, Sun, Lu, Liu, Ergang, Wang, Jianxin, Huang, Yongzhuo, Lee, Seung Jin, He, Huining
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985694/
https://ncbi.nlm.nih.gov/pubmed/29872628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2017.11.011
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