Improved method for synthesis of low molecular weight protamine–siRNA conjugate

RNAi technology has aroused wide public interest due to its high efficiency and specificity to treat multiple types of diseases. However, the effective delivery of siRNA remains a challenge due to its large molecular weight and strong anionic charge. Considering their remarkable functions in vivo an...

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Bibliografiske detaljer
Udgivet i:Acta Pharm Sin B
Main Authors: Yu, Zhili, Ye, Junxiao, Pei, Xing, Sun, Lu, Liu, Ergang, Wang, Jianxin, Huang, Yongzhuo, Lee, Seung Jin, He, Huining
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985694/
https://ncbi.nlm.nih.gov/pubmed/29872628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2017.11.011
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