Loss of Akap1 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure

Left ventricular hypertrophy (LVH) is a major contributor to the development of heart failure (HF). Alterations in cyclic adenosine monophosphate (cAMP)-dependent signaling pathways participate in cardiomyocyte hypertrophy and mitochondrial dysfunction occurring in LVH and HF. cAMP signals are recei...

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Veröffentlicht in:Front Physiol
Hauptverfasser: Schiattarella, Gabriele G., Boccella, Nicola, Paolillo, Roberta, Cattaneo, Fabio, Trimarco, Valentina, Franzone, Anna, D’Apice, Stefania, Giugliano, Giuseppe, Rinaldi, Laura, Borzacchiello, Domenica, Gentile, Alessandra, Lombardi, Assunta, Feliciello, Antonio, Esposito, Giovanni, Perrino, Cinzia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985454/
https://ncbi.nlm.nih.gov/pubmed/29892230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.00558
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