Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease

OBJECTIVE: Mutations to the BSCL2 gene disrupt the protein seipin and cause the most severe form of congenital generalised lipodystrophy (CGL). Affected individuals exhibit a near complete loss of white adipose tissue (WAT) and suffer from metabolic disease. Seipin is critical for adipocyte developm...

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Publicado en:Mol Metab
Main Authors: Mcilroy, George D., Suchacki, Karla, Roelofs, Anke J., Yang, Wulin, Fu, Yanyun, Bai, Bo, Wallace, Robert J., De Bari, Cosimo, Cawthorn, William P., Han, Weiping, Delibegović, Mirela, Rochford, Justin J.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2018
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985228/
https://ncbi.nlm.nih.gov/pubmed/29459250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.01.019
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