The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates

OBJECTIVE: To characterize the EndoC-βH1 cell line as a model for human beta cells and evaluate its beta cell functionality, focusing on insulin secretion, proliferation, apoptosis and ER stress, with the objective to assess its potential as a screening platform for identification of novel anti-diab...

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Publicado en:Mol Metab
Autores principales: Tsonkova, Violeta Georgieva, Sand, Fredrik Wolfhagen, Wolf, Xenia Asbæk, Grunnet, Lars Groth, Kirstine Ringgaard, Anna, Ingvorsen, Camilla, Winkel, Louise, Kalisz, Mark, Dalgaard, Kevin, Bruun, Christine, Fels, Johannes Josef, Helgstrand, Charlotte, Hastrup, Sven, Öberg, Fredrik Kryh, Vernet, Erik, Sandrini, Michael Paolo Bastner, Shaw, Allan Christian, Jessen, Carsten, Grønborg, Mads, Hald, Jacob, Willenbrock, Hanni, Madsen, Dennis, Wernersson, Rasmus, Hansson, Lena, Jensen, Jan Nygaard, Plesner, Annette, Alanentalo, Tomas, Petersen, Maja Borup Kjær, Grapin-Botton, Anne, Honoré, Christian, Ahnfelt-Rønne, Jonas, Hecksher-Sørensen, Jacob, Ravassard, Philippe, Madsen, Ole D., Rescan, Claude, Frogne, Thomas
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985049/
https://ncbi.nlm.nih.gov/pubmed/29307512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.12.007
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