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Propagation of an Aβ Dodecamer Strain Involves a Three-Step Mechanism and a Key Intermediate
Proteinaceous deposits composed of fibrillar amyloid-β (Aβ) are the primary neuropathological hallmarks in Alzheimer disease (AD) brains. The nucleation-dependent aggregation of Aβ is a stochastic process with frequently observed heterogeneity in aggregate size, structure, and conformation that mani...
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| Publicado en: | Biophys J |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Biophysical Society
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5985009/ https://ncbi.nlm.nih.gov/pubmed/29414699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.11.3778 |
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