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Strain-specific Fibril Propagation by an Aβ Dodecamer

Low molecular weight oligomers of amyloid-β (Aβ) have emerged as the primary toxic agents in the etiology of Alzheimer disease (AD). Polymorphism observed within the aggregation end products of fibrils are known to arise due to microstructural differences among the oligomers. Diversity in aggregate...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dean, Dexter N., Das, Pradipta K., Rana, Pratip, Burg, Franklin, Levites, Yona, Morgan, Sarah E., Ghosh, Preetam, Rangachari, Vijayaraghavan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241678/
https://ncbi.nlm.nih.gov/pubmed/28098204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40787
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