Co-targeting BCL-2 and PI3K induces BAX-dependent mitochondrial apoptosis in AML cells

Inhibitors targeting BCL-2 apoptotic proteins have significant potential for the treatment of acute myeloid leukemia (AML); however, complete responses are observed in only 20% of patients suggesting targeting BCL-2 alone is insufficient to yield durable responses. Here we assessed the efficacy of c...

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Udgivet i:Cancer Res
Main Authors: Rahmani, Mohamed, Nkwocha, Jewel, Hawkins, Elisa, Pei, Xinyan, Parker, Rebecca E., Kmieciak, Maciej, Leverson, Joel D., Sampath, Deepak, Ferreira-Gonzalez, Andrea, Grant, Steven
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984704/
https://ncbi.nlm.nih.gov/pubmed/29559471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-3024
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