Targeted therapies for targeted populations: Anti-EGFR treatment for EGFR amplified gastroesophageal adenocarcinoma

Previous anti-EGFR trials in unselected gastroesophageal adenocarcinoma (GEA) patients were resoundingly negative. We identified EGFR amplification in 5% (19/363) of patients at the University of Chicago, including 6% (8/140) who were prospectively screened with intention-to-treat using anti-EGFR th...

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Bibliografiske detaljer
Udgivet i:Cancer Discov
Main Authors: Maron, Steven B., Alpert, Lindsay, Kwak, Heewon A., Lomnicki, Samantha, Chase, Leah, Xu, David, O’Day, Emily, Nagy, Rebecca J., Lanman, Richard B., Cecchi, Fabiola, Hembrough, Todd, Schrock, Alexa, Hart, John, Xiao, Shu-Yuan, Setia, Namrata, Catenacci, Daniel V.T.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984701/
https://ncbi.nlm.nih.gov/pubmed/29449271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-1260
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