Targeted therapies for targeted populations: Anti-EGFR treatment for EGFR amplified gastroesophageal adenocarcinoma

Previous anti-EGFR trials in unselected gastroesophageal adenocarcinoma (GEA) patients were resoundingly negative. We identified EGFR amplification in 5% (19/363) of patients at the University of Chicago, including 6% (8/140) who were prospectively screened with intention-to-treat using anti-EGFR th...

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Gepubliceerd in:Cancer Discov
Hoofdauteurs: Maron, Steven B., Alpert, Lindsay, Kwak, Heewon A., Lomnicki, Samantha, Chase, Leah, Xu, David, O’Day, Emily, Nagy, Rebecca J., Lanman, Richard B., Cecchi, Fabiola, Hembrough, Todd, Schrock, Alexa, Hart, John, Xiao, Shu-Yuan, Setia, Namrata, Catenacci, Daniel V.T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984701/
https://ncbi.nlm.nih.gov/pubmed/29449271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-1260
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