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Augmented Th17 Differentiation Leads to Cutaneous and Synovio-Entheseal Inflammation in a Novel Model of Psoriatic Arthritis

OBJECTIVE: To introduce a novel pre-clinical animal model of psoriatic arthritis, R26STAT3C(stopfl/fl) CD4Cre mice, and investigate the role of Th17 cytokines in the disease pathogenesis. METHODS: We characterized a novel murine model of Th17-driven cutaneous and synovio-entheseal disease directed b...

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發表在:Arthritis Rheumatol
Main Authors: Yang, Lu, Fanok, Melania H., Mediero-Munoz, Aranzazu, Fogli, Laura K, Corciulo, Carmen, Abdollahi, Shahla, Cronstein, Bruce N., Scher, Jose U., Koralov, Sergei B.
格式: Artigo
語言:Inglês
出版: 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984671/
https://ncbi.nlm.nih.gov/pubmed/29439292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40447
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