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Synthesis and preliminary cytotoxicity study of a cephalosporin-CC-1065 analogue prodrug

BACKGROUND: Antibody-directed enzyme prodrug therapy (ADEPT) is a promising new approach to deliver anticancer drugs selectively to tumor cells. In this approach, an enzyme is conjugated to a tumor-specific antibody. The antibody selectively localizes the enzyme to the tumor cell surface. Subsequent...

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Bibliografski detalji
Glavni autori: Wang, Yuqiang, Yuan, Huiling, Wright, Susan C, Wang, Hong, Larrick, James W
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2001
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC59845/
https://ncbi.nlm.nih.gov/pubmed/11710971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6769-1-4
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