Isolation of state-dependent monoclonal antibodies against the 12-transmembrane domain glucose transporter 4 using virus-like particles

The insulin-responsive 12-transmembrane transporter GLUT4 changes conformation between an inward-open state and an outward-open state to actively facilitate cellular glucose uptake. Because of the difficulties of generating conformational mAbs against complex and highly conserved membrane proteins,...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Tucker, David F., Sullivan, Jonathan T., Mattia, Kimberly-Anne, Fisher, Christine R., Barnes, Trevor, Mabila, Manu N., Wilf, Rona, Sulli, Chidananda, Pitts, Meghan, Payne, Riley J., Hall, Moniquetta, Huston-Paterson, Duncan, Deng, Xiaoxiang, Davidson, Edgar, Willis, Sharon H., Doranz, Benjamin J., Chambers, Ross, Rucker, Joseph B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2018
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984492/
https://ncbi.nlm.nih.gov/pubmed/29769329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716788115
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