Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma

Competitive BET bromodomain inhibitors (BBIs) targeting BET proteins (BRD2, BRD3, BRD4, and BRDT) show promising preclinical activities against brain cancers. However, the BET protein-dependent glioblastoma (GBM)-promoting transcriptional network remains elusive. Here, with mechanistic exploration o...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Xu, Liang, Chen, Ye, Mayakonda, Anand, Koh, Lynnette, Chong, Yuk Kien, Buckley, Dennis L., Sandanaraj, Edwin, Lim, See Wee, Lin, Ruby Yu-Tong, Ke, Xin-Yu, Huang, Mo-Li, Chen, Jianxiang, Sun, Wendi, Wang, Ling-Zhi, Goh, Boon Cher, Dinh, Huy Q., Kappei, Dennis, Winter, Georg E., Ding, Ling-Wen, Ang, Beng Ti, Berman, Benjamin P., Bradner, James E., Tang, Carol, Koeffler, H. Phillip
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984485/
https://ncbi.nlm.nih.gov/pubmed/29764999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712363115
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