Advanced Glycation Endproducts Are Increased in the Animal Model of Multiple Sclerosis but Cannot Be Reduced by Pyridoxamine Treatment or Glyoxalase 1 Overexpression

Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system (CNS). The immune response in MS patients leads to the infiltration of immune cells in the CNS and their subsequent activation. Immune cell activation induces a switch towards glycolysis. During glycolysis, t...

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Udgivet i:Int J Mol Sci
Main Authors: Wetzels, Suzan, Wouters, Kristiaan, Miyata, Toshio, Scheijen, Jean L. J. M., Hendriks, Jerome J. A., Schalkwijk, Casper G., Vanmierlo, Tim
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983766/
https://ncbi.nlm.nih.gov/pubmed/29702605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19051311
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