SOD1 in Amyotrophic Lateral Sclerosis: “Ambivalent” Behavior Connected to the Disease

In 1993, Rosen and collaborators discovered that the gene encoding SOD1 has mutations in amyotrophic lateral sclerosis (ALS) patients; moreover, these mutations are found in the exon regions, suggesting that their toxic effects are the consequence of protein dysfunction with an increase of oxidative...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Pansarasa, Orietta, Bordoni, Matteo, Diamanti, Luca, Sproviero, Daisy, Gagliardi, Stella, Cereda, Cristina
Format: Artigo
Language:Inglês
Published: MDPI 2018
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983710/
https://ncbi.nlm.nih.gov/pubmed/29751510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19051345
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