A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib

There is a great unmet medical need in pancreatic carcinoma (PC) for novel drugs with other mechanisms of action than existing. PC cells express the onco-fetal RTK ROR1, absent on most normal post-partem cells. ROR1 is involved in proliferation, survival, EMT and metastasis of tumor cells in various...

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Publicado en:PLoS One
Autores principales: Daneshmanesh, Amir Hossein, Hojjat-Farsangi, Mohammad, Ghaderi, Amineh, Moshfegh, Ali, Hansson, Lotta, Schultz, Johan, Vågberg, Jan, Byström, Styrbjörn, Olsson, Elisabeth, Olin, Thomas, Österborg, Anders, Mellstedt, Håkan
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983484/
https://ncbi.nlm.nih.gov/pubmed/29856777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198038
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