Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder

Major depressive disorder (MDD) has been linked to mitochondrial defects, which could manifest in mitochondrial DNA (mtDNA) polymorphisms or mutations. Additionally, copy number of mtDNA (mtDNA-cn) can be quantified in peripheral blood mononuclear cells (PBMC)s, indirectly reflecting cellular energe...

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Опубликовано в: :Neuropsychopharmacology
Главные авторы: Lindqvist, Daniel, Wolkowitz, Owen M., Picard, Martin, Ohlsson, Lars, Bersani, Francesco S., Fernström, Johan, Westrin, Åsa, Hough, Christina M., Lin, Jue, Reus, Victor I., Epel, Elissa S., Mellon, Synthia H.
Формат: Artigo
Язык:Inglês
Опубликовано: Springer International Publishing 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983469/
https://ncbi.nlm.nih.gov/pubmed/29453441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-017-0001-9
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