Blocking IFNAR1 inhibits multiple myeloma–driven Treg expansion and immunosuppression

Despite significant advances in the treatment of multiple myeloma (MM), most patients succumb to disease progression. One of the major immunosuppressive mechanisms that is believed to play a role in myeloma progression is the expansion of regulatory T cells (Tregs). In this study, we demonstrate tha...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Kawano, Yawara, Zavidij, Oksana, Park, Jihye, Moschetta, Michele, Kokubun, Katsutoshi, Mouhieddine, Tarek H., Manier, Salomon, Mishima, Yuji, Murakami, Naoka, Bustoros, Mark, Pistofidis, Romanos Sklavenitis, Reidy, Mairead, Shen, Yu J., Rahmat, Mahshid, Lukyanchykov, Pavlo, Karreci, Esilida Sula, Tsukamoto, Shokichi, Shi, Jiantao, Takagi, Satoshi, Huynh, Daisy, Sacco, Antonio, Tai, Yu-Tzu, Chesi, Marta, Bergsagel, P. Leif, Roccaro, Aldo M., Azzi, Jamil, Ghobrial, Irene M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983341/
https://ncbi.nlm.nih.gov/pubmed/29558366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88169
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