HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers

Autophagy is important for liver homeostasis, and the deficiency leads to injury, inflammation, ductular reaction (DR), fibrosis, and tumorigenesis. It is not clear how these events are mechanistically linked to autophagy deficiency. Here, we reveal the role of high-mobility group box 1 (HMGB1) in t...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Khambu, Bilon, Huda, Nazmul, Chen, Xiaoyun, Li, Yong, Dai, Guoli, Köhler, Ulrike A., Zong, Wei-Xing, Waguri, Satoshi, Werner, Sabine, Oury, Tim D., Dong, Zheng, Yin, Xiao-Ming
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983330/
https://ncbi.nlm.nih.gov/pubmed/29558368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI91814
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