HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers

Autophagy is important for liver homeostasis, and the deficiency leads to injury, inflammation, ductular reaction (DR), fibrosis, and tumorigenesis. It is not clear how these events are mechanistically linked to autophagy deficiency. Here, we reveal the role of high-mobility group box 1 (HMGB1) in t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Khambu, Bilon, Huda, Nazmul, Chen, Xiaoyun, Li, Yong, Dai, Guoli, Köhler, Ulrike A., Zong, Wei-Xing, Waguri, Satoshi, Werner, Sabine, Oury, Tim D., Dong, Zheng, Yin, Xiao-Ming
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983330/
https://ncbi.nlm.nih.gov/pubmed/29558368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI91814
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