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HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers
Autophagy is important for liver homeostasis, and the deficiency leads to injury, inflammation, ductular reaction (DR), fibrosis, and tumorigenesis. It is not clear how these events are mechanistically linked to autophagy deficiency. Here, we reveal the role of high-mobility group box 1 (HMGB1) in t...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5983330/ https://ncbi.nlm.nih.gov/pubmed/29558368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI91814 |
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