Molecular Mechanisms of Apoptosis in HepaRG Cell Line Induced by Polyphyllin VI via the Fas Death Pathway and Mitochondrial-Dependent Pathway

Polyphyllin VI, which is an active saponin, is mainly isolated from traditional medicinal plant Paris polyphylla, which causes liver damage in rats. In the present study, we aimed to explore the potential cytotoxicity of polyphyllin VI on the growth of HepaRG cells and to determine the molecular mec...

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Vydáno v:Toxins (Basel)
Hlavní autoři: Liu, Yi, Dong, Xiaoxv, Wang, Wenping, You, Longtai, Yin, Xingbin, Yang, Chunjing, Sai, Na, Leng, Xin, Ni, Jian
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5983257/
https://ncbi.nlm.nih.gov/pubmed/29762502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins10050201
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