Epigenetic reprogramming by naïve conditions establishes an irreversible state of partial X chromosome reactivation in female stem cells

Female human pluripotent stem cells (PSCs) have variable X-chromosome inactivation (XCI) status. One of the X chromosomes may either be inactive (Xi) or display some active state markers. Long-term cultivation of PSCs may lead to an erosion of XCI and partial X reactivation. Such heterogeneity and i...

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Vydáno v:Oncotarget
Hlavní autoři: Panova, Alexandra V., Bogomazova, Alexandra N., Lagarkova, Maria A., Kiselev, Sergey L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5982739/
https://ncbi.nlm.nih.gov/pubmed/29861859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25353
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