The Anticoagulant Protein S Targets the Factor IXa Heparin-Binding Exosite to Prevent Thrombosis

OBJECTIVE: Protein S (PS) is a plasma protein that directly inhibits the coagulation factor IXa (FIXa) in vitro. Because elevated FIXa is associated with increased risk of venous thromboembolism, it is important to establish how PS inhibits FIXa function in vivo. The goal of this work is to confirm...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Plautz, William E., Pilli, Vijaya Satish Sekhar, Cooley, Brian C., Chattopadhyay, Rima, Westmark, Pamela R., Getz, Todd, Paul, David, Bergmeier, Wolfgang, Sheehan, John P., Majumder, Rinku
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5982114/
https://ncbi.nlm.nih.gov/pubmed/29419409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.310588
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