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The heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis
The role of the factor IXa heparin-binding exosite in coagulation was assessed with mutations that enhance (R170A) or reduce (R233A) stability of the protease-factor VIIIa A2 domain interaction. After tissue factor (TF) addition to reconstituted factor IX-deficient plasma, factor IX R170A supported...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society of Hematology
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2569175/ https://ncbi.nlm.nih.gov/pubmed/18647957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-136820 |
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