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The heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis

The role of the factor IXa heparin-binding exosite in coagulation was assessed with mutations that enhance (R170A) or reduce (R233A) stability of the protease-factor VIIIa A2 domain interaction. After tissue factor (TF) addition to reconstituted factor IX-deficient plasma, factor IX R170A supported...

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Bibliografiske detaljer
Main Authors: Buyue, Yang, Whinna, Herbert C., Sheehan, John P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569175/
https://ncbi.nlm.nih.gov/pubmed/18647957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-136820
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