Direct phenotypic conversion of human fibroblasts into functional osteoblasts triggered by a blockade of the transforming growth factor-β signal

A procedure to generate functional osteoblasts from human somatic cells may pave the way to a novel and effective transplantation therapy in bone disorders. Here, we report that human fibroblasts were induced to show osteoblast phenotypes by culturing with ALK5 i II, which is a specific inhibitor fo...

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Publicat a:Sci Rep
Autors principals: Yamamoto, Kenta, Kishida, Tsunao, Nakai, Kei, Sato, Yoshiki, Kotani, Shin-ichiro, Nishizawa, Yuta, Yamamoto, Toshiro, Kanamura, Narisato, Mazda, Osam
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5981640/
https://ncbi.nlm.nih.gov/pubmed/29855543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26745-2
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