Direct conversion of human fibroblasts into functional osteoblasts by defined factors

Osteoblasts produce calcified bone matrix and contribute to bone formation and remodeling. In this study, we established a procedure to directly convert human fibroblasts into osteoblasts by transducing some defined factors and culturing in osteogenic medium. Osteoblast-specific transcription factor...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yamamoto, Kenta, Kishida, Tsunao, Sato, Yoshiki, Nishioka, Keisuke, Ejima, Akika, Fujiwara, Hiroyoshi, Kubo, Toshikazu, Yamamoto, Toshiro, Kanamura, Narisato, Mazda, Osam
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434770/
https://ncbi.nlm.nih.gov/pubmed/25918395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420713112
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