Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma

Chimeric antigen receptor (CAR) T-cell therapy has been shown to be dramatically effective in the treatment of B-cell malignancies. However, there are still substantial obstacles to overcome, before similar responses can be achieved in patients with solid tumors. We evaluated both in vitro and in a...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Oncoimmunology
Päätekijät: Quintarelli, Concetta, Orlando, Domenico, Boffa, Iolanda, Guercio, Marika, Polito, Vinicia Assunta, Petretto, Andrea, Lavarello, Chiara, Sinibaldi, Matilde, Weber, Gerrit, Del Bufalo, Francesca, Giorda, Ezio, Scarsella, Marco, Petrini, Stefania, Pagliara, Daria, Locatelli, Franco, De Angelis, Biagio, Caruana, Ignazio
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Taylor & Francis 2018
Aiheet:
Original Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980417/
https://ncbi.nlm.nih.gov/pubmed/29872565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1433518
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