Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma

Chimeric antigen receptor (CAR) T-cell therapy has been shown to be dramatically effective in the treatment of B-cell malignancies. However, there are still substantial obstacles to overcome, before similar responses can be achieved in patients with solid tumors. We evaluated both in vitro and in a...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Quintarelli, Concetta, Orlando, Domenico, Boffa, Iolanda, Guercio, Marika, Polito, Vinicia Assunta, Petretto, Andrea, Lavarello, Chiara, Sinibaldi, Matilde, Weber, Gerrit, Del Bufalo, Francesca, Giorda, Ezio, Scarsella, Marco, Petrini, Stefania, Pagliara, Daria, Locatelli, Franco, De Angelis, Biagio, Caruana, Ignazio
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980417/
https://ncbi.nlm.nih.gov/pubmed/29872565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1433518
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