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The intestinal microbiota determines the clinical efficacy of immune checkpoint blockers targeting PD-1/PD-L1

Cancer immunotherapists have been searching for biomarkers predicting patient responses to PD-1/PD-L1 blockade in neoplastic cells as well as in the immune system. Now, accumulating evidence indicates that the composition of the intestinal microflora has a major impact on patient prognosis. Here, we...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Derosa, Lisa, Routy, Bertrand, Kroemer, Guido, Zitvogel, Laurence
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980343/
https://ncbi.nlm.nih.gov/pubmed/29872574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1434468
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