Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids

Transport of biologically active molecules across tight epithelial barriers is a major challenge preventing therapeutic peptides from oral drug delivery. Here, we identify a set of synthetic glycosphingolipids that harness the endogenous process of intracellular lipid-sorting to enable mucosal absor...

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Vydáno v:eLife
Hlavní autoři: Garcia-Castillo, Maria Daniela, Chinnapen, Daniel J-F, te Welscher, Yvonne M, Gonzalez, Rodrigo J, Softic, Samir, Pacheco, Michele, Mrsny, Randall J, Kahn, C Ronald, von Andrian, Ulrich H, Lau, Jesper, Pentelute, Bradley L, Lencer, Wayne I
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2018
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980230/
https://ncbi.nlm.nih.gov/pubmed/29851380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34469
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